Translational Research Bioinformatician
At a glance
- Band
- Band 7
- Contract
- Fixed-term
- Pattern
- Full-time, Flexible working
- Posted
- 15/09/2026
- Closes
- 27/09/2026
Sponsorship verdict
Candidates needing sponsorship are encouraged to apply.
HiveMind found a sponsorship-friendly statement in the source advert welcoming applicants who require a visa. Always confirm on the source before applying.
“Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications.”Quoted verbatim from the source advert
Role summary
This role is for a Translational Research Bioinformatician to support the NHS Genomics Networks of Excellence project, focusing on rapid whole genome sequencing and methylation for precision treatments in childhood cancer. The successful candidate will process Illumina TruPath genome data through analysis pipelines, prepare results for MDT discussions, and operate within a regulated clinical bioinformatics environment. Experience with large, complex data and clinically-relevant timelines is expected. This is an 18-month fixed-term contract.
Key responsibilities
- Develop specialist clinical bioinformatics tools and workflows.
- Perform specialist analysis of genomic data, including secondary and tertiary bioinformatics.
- Continuously improve specialist clinical bioinformatics tools, processes, and workflows for genomic diagnostic services.
- Investigate and resolve complex bioinformatics issues through specialist examination of data and processes, communicating with technical, scientific, and clinical staff.
- Plan and manage bioinformatics development projects, interfacing with technical, scientific, and clinical functions of the genomic laboratory.
- Contribute to and facilitate appropriate local and national data sharing programmes.
Essential criteria
- Postgraduate degree / PhD in bioinformatics,
- Postgraduate qualification in bioinformatics or an appropriate biological science or equivalent experience with skills in developing new workflows and pipelines
- Has developed bioinformatics tools and/or resources
- Has implemented bioinformatics tools and/or resources
- Has experience of performing specialist analysis and interpretation of genomic data
- Has experience of performing bioinformatics analysis of next generation sequencing data
- Has developed software using an object-oriented language such as Python Has developed relational databases with tools such as MySQL/MariaDB
- Has experience of using tools such as R and pandas to perform programmatic statistical analysis of genomic data
- Has experience of effective, structured project management
- Basic knowledge of human genetics and the effects of genetic variation
- Practical knowledge of programming and coding
- Practical knowledge of statistics for data analysis
- Knowledge of next generation sequencing technologies
- Knowledge and understanding of secondary bioinformatics analysis of data generated by next generation sequencing technologies
- Knowledge and understanding of tertiary bioinformatics analysis of data generated by next generation sequencing technologies
- Knowledge and awareness of the breadth of bioinformatics tools available for the analysis and interpretation of genomic data
- Write object-orientated code to a high standard
- Query databases programmatically
- Alignment of next generation sequencing data
- Variant calling from next generation sequencing data
- Programmatic annotation of variants
- Programmatic filtering and prioritisation of variants
- Assessment of impact and clinical interpretation of variants
- Optimise bioinformatics tools for application in local pipelines
- Develop new bioinformatics tools
- Analyse complex genomics data to answer clinical bioinformatics questions
- Organise and manage delivery of complex projects
- Maintain concentration and focus under pressure
- Provide leadership to peers
- Deliver training to colleagues
- Present complex scientific and clinical information to specialist and non-specialist audiences
- Good verbal and written communication skills
- Create and accurately follow documentation and SOPs
- The ability to understand and behave at all times, towards patients, visitors and colleagues according to the Trust values of safe, kind, excellent.
Desirable criteria
- Completion of Health Education England's Scientist Training Programme in Clinical Bioinformatics Genomics or equivalent training programme
- HCPC clinical scientist registration or is working towards registration
- Has experience of working within a diagnostic genomic laboratory
- Has experience of specialist analysis and interpretation of genomic data in a healthcare setting
- Has experience of using automated, reproducible workflow management systems Has experience of performing bioinformatics analysis using cloud compute
- Has developed software collaboratively using a version control system such as git
- Has experience of clinical quality management systems
- Has used project management and team collaboration tools such as JIRA and Confluence
- Broad knowledge and in-depth understanding of how different types genetic variation can lead to various genetic rare diseases and cancer
- Knowledge of clinical requirements for bioinformatics applications used for diagnostic services
- Familiar with requirements for accreditation of bioinformatics processes to the ISO 15189 standard
- In-depth knowledge of best practice guidance for development and application of bioinformatics tools in clinical laboratories
- Applied knowledge of good management practices
- Knowledge of data security and information governance requirements for clinical data
- Clinically evaluate software for use in delivery of diagnostic services
- Perform code review and provide constructive feedback to peers to improve the quality of code
- Observe and systematically examine processes to propose improvements for clinical service delivery
- Develop bioinformatics policy to guide the practice of clinical bioinformatics
- Respond to queries from end users of bioinformatics software and communicate effectively to resolve issues and deliver against requirements.
Useful to know
Agenda for Change 2024/25 pays Band 7 at £46,148 – £52,809 a year, across England.
This advert: £49,387 – £56,515 — outside the standard scale; check for HCAS/London weighting.
Posted 1d ago · Closes in 12d
Plenty of time to prepare a strong application.
Full advert · preview
Cambridge University Hospital NHS Foundation Trust
Translational Research Bioinformatician
The closing date is 27 September 2026
Job summary
Opportunity for a translational research bioinformatician to support the NHS Genomics Networks of Excellence project: rapid whole genome sequencing and methylation to enable precision treatments in childhood cancer. The role will include processing Illumina TruPath genome data through secondary and tertiary analysis pipelines, preparing results for MDT discussion, operating in a regulated clinical bioinformatics environment. Applicants are expected to have experience working with large, complex data within clinically-relevant timelines.
This is an 18-month contract (finishing March 2028)
Main duties of the job
- Development of specialist clinical bioinformatics tools and workflows
- Specialist analysis of genomic data: secondary and tertiary bioinformatics
- Continued improvement of specialist clinical bioinformatics tools processes and workflows for delivery of genomic diagnostic services
- Investigation and resolution of complex bioinformatics issues by specialist examination of input & output data, and associated bioinformatics processes; includes communication with technical, scientific and clinical staff
- Planning and management of bioinformatics development projects; includes interfacing with technical, scien
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